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Orchestra BioOrchestra BioSan Francisco, CA

Senior Backend Engineer

Senior Backend Engineer builds scalable backend systems for R&D management platform in biotech, modeling complex decisions, aligning organizations, and integrating AI/LLMs for scenario analysis and insights. Requires 6+ years experience with TypeScript, NestJS, PostgreSQL, and cloud platforms.

Salary not listed
Hybrid6+ YOEBackend Engineering

About the role

Responsibilities

  • Build interactive tools for modeling paths to market, assessing trade-offs between time, money, and technical risk.
  • Create intuitive interfaces for organizational alignment, visualizing complex dependencies and progress across teams (scientists, program managers, executives).
  • Design interfaces for scientists to manage studies, track progress, and coordinate teams.
  • Leverage LLMs to generate/evaluate scenarios, infer progress/risks from unstructured data, and surface insights from R&D portfolio.

Requirements

Required:

  • 6-8 years of backend development experience with production systems at scale.
  • Deep expertise in Typescript, NestJS, PostgreSQL.
  • Track record of building complex, scalable, reliable cloud-based software.
  • Experience with cloud platforms (AWS/Azure/GCP) and containerization.
  • Strong experience in data modeling and API design.
  • Collaborative mindset with proven track record in small, fast-moving engineering teams.

Preferred:

  • AI/ML integration with OpenAI, Anthropic, or similar LLM providers.
  • Prompt engineering and RAG implementation experience.
  • Full-stack capabilities (React/TypeScript).
  • Track record of mentoring other engineers.

Skills

TypeScriptNestjsPostgresAWSAzureGCPContainerizationData ModelingAPI DesignReactOpenAIAnthropicRAG
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