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Radial Postdoctoral Fellow – Dynamic Structural Biology (diffUSE Project)

70k – 70kIthaca, NYOtherOnsite
Summary

Conducts advanced X-ray crystallography experiments to study protein dynamics in the diffUSE project, including crystal growth, synchrotron data collection, and computational modeling of conformational ensembles. Requires PhD in structural biology or related field with hands-on crystallography experience.

About the role

Responsibilities

  • Design and execute experiments to probe protein dynamics using X-ray crystallography, including crystal growth, optimization, and data collection
  • Collect and analyze diffraction data (including diffuse scattering) at synchrotron facilities
  • Apply and/or develop computational tools for modeling conformational ensembles from experimental data
  • Collaborate with interdisciplinary teams across the diffUSE Project (experimental, computational, and theoretical groups)
  • Contribute to method development and benchmarking for dynamic structural biology
  • Mentor graduate and undergraduate students in the team
  • Communicate results through open-science platforms

Required Qualifications

  • PhD in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field
  • Demonstrated experience with X-ray crystallography (data collection, processing, refinement)
  • Strong experimental skills in protein expression, purification, and/or crystallization
  • Ability to think rigorously about physical models and experimental data
  • Strong written and verbal communication skills
  • Ability to work effectively in a collaborative, interdisciplinary environment

Preferred Qualifications

  • Experience with advanced X-ray instrumentation
  • Experience developing experimental or theoretical approaches for dynamic structural biology (such as time-resolved X-FEL, energy landscapes by cryo-EM)
  • Experience with scientific programming (Python, MATLAB, etc.)
  • Engagement in open-science practices

Compensation

  • Salary: $70K
Skills
X-ray crystallographysynchrotron data collectionprotein expressionprotein purificationprotein crystallizationdiffuse scatteringPythonMATLABmolecular dynamics simulationscryo-EMSAXS
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