Astera
Neuroscience and AI research institute advancing brain-like AGI
Astera Institute conducts in-house research at the intersection of neuroscience and artificial intelligence to understand biological intelligence and engineer safe AGI systems. Through divisions like Neuro & AGI and Radial, they run labs on rodent neuroscience, structural biology ML, hierarchical RL, and open science tools. Their work integrates experimental neuroscience with AI architectures to drive transformative progress in intelligence and life sciences.
Recruiting Coordinator
Build and operate Astera’s recruiting engine, owning candidate scheduling, communication, pipeline tracking in Ashby, and logistics for twice-annual residency cohorts. Requires 2+ years in operations or executive support with exceptional organization and communication skills.
Project Manager - DiffUSE Project
The Project Manager will coordinate efforts across a multidisciplinary team for The DiffUSE Project, ensuring strategic alignment, managing project plans, budgets, and communications, and fostering a collaborative environment.
General DiffUSE Job Application
Open general application for computational biology, ML research, data science, software engineering, and program roles at DiffUSE, focused on protein dynamics, structural data infrastructure, and open science tooling.
Computational Neuroscience Intern - Data Analysis and Modeling
Analyzes large-scale connectome and neurophysiology datasets, develops computational models of neural circuits, and implements data pipelines using Python/Matlab. Ideal for students in computational neuroscience or related fields with data analysis experience.
Software Engineering Intern – Distributed Simulation Systems
Software Engineering Intern builds infrastructure for large-scale distributed simulation systems including biological and 3D physics environments. Works on C++ high-performance systems, networking, orchestration, and performance optimization with strong fundamentals required.
Software Engineer — Distributed Simulation Systems
Builds core infrastructure for large-scale distributed simulation systems, including biological and 3D physics environments. Requires strong C++ systems programming, distributed computing, high-performance networking, and experience with MuJoCo or similar simulators.
Research Scientist / Engineer, Two-Photon Imaging & Holographic Optogenetics
Leads development of miniaturized two-photon microscopes for cellular-resolution imaging and holographic optogenetics in rodents. Requires PhD, hands-on surgery experience, two-photon systems expertise, and neural data analysis skills in Python/MATLAB.
Radial Postdoctoral Fellow – Dynamic Structural Biology (diffUSE Project)
Conducts advanced X-ray crystallography experiments to study protein dynamics in the diffUSE project, including crystal growth, synchrotron data collection, and computational modeling of conformational ensembles. Requires PhD in structural biology or related field with hands-on crystallography experience.
Machine Learning Researcher - Springtail
Conducts fundamental research on data-efficient ML architectures, including bootstrapped program synthesis and self-synthesizing learning systems. Requires Master's in ML/math, PyTorch fluency, and research experience.
Head of Bio AI - Radial
Leads technical direction for bio AI research programs, architects AI/computational infrastructure, prototypes modeling systems, and builds high-caliber engineering team. Requires deep ML expertise in generative models, large-scale training, and bio applications with hands-on leadership.
Scientist - Ensemble Structural Informatics
Leads development of standards and validation frameworks for dynamic structural biology data, focusing on ensemble models from X-ray crystallography and cryo-EM. Collaborates with engineers to build deposition, search, and retrieval infrastructure for the diffUSE Project. Requires PhD in structural biology or related field.
Research Scientist: Hierarchical Sensorimotor Perception
Develops bi-directional/recurrent architectures for hierarchical sensorimotor perception inspired by brain principles to advance AGI. Requires PhD-level expertise in deep learning frameworks like PyTorch/JAX, theoretical rigor, and passion for biological intelligence.
Research Scientist: Hierarchical RL Agents
Conducts fundamental research on hierarchical RL agents, developing architectures for world modeling, planning, and ethologically constrained learning. Collaborates cross-functionally to translate brain-inspired principles into scalable AGI systems; requires PhD-level expertise in AI/ML and strong coding skills.
Research Scientist/Engineer
Conducts fundamental research on brain-inspired world models and AGI architectures, designing experiments on cognition, causal representations, and unsupervised learning. Collaborates with neuroscientists and engineers; requires PhD-level expertise in deep learning frameworks like PyTorch/JAX.
Research Scientist: Energy Based Models
Conducts fundamental research on neuroscience-inspired energy-based models and hierarchical latent variable models for AGI. Designs experiments on cognition and collaborates cross-functionally to build scalable systems. Requires PhD-level expertise in deep learning and PyTorch/JAX.
Research Scientist - Simplex
Develops theories of intelligence grounded in neural network internal structures, focusing on belief geometries in LLMs and biological brains. Conducts experiments bridging mathematics, ML interpretability, and safety research; requires PhD-level quantitative depth and hands-on coding.
Site Reliability Engineer
Owns digital infrastructure for AI research, managing compute access, auto-scaling, resource visibility, and reproducibility using Kubernetes and observability tools. Requires systems intuition, operational rigor, and pragmatism for experimental workloads.
Staff Software Engineer
Staff Software Engineer architects high-performance infrastructure for large-scale Neuro-AI models and simulations, optimizes RL environments informed by neuroscience, and scales research prototypes to production while resolving technical bottlenecks.
Senior Software Engineer
Builds high-performance infrastructure for brain reverse-engineering via large-scale AI models and neuroscience-informed simulations. Architects systems, optimizes RL environments, and scales research prototypes to production.
Principal Software Engineer
Architects high-performance infrastructure for training large-scale neuroscience-informed AI models and RL environments. Optimizes code, resolves critical bottlenecks, and scales research prototypes to production systems.
The Stacks Product Manager
Leads vision, strategy, and execution for The Stacks, an open-access platform for scientific knowledge. Translates user needs into roadmaps, collaborates with engineering/design, conducts research, and ensures high usability. Requires 4-7+ years PM experience in content/research tools and technical fluency.