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AsteraAsteraEmeryville, CA

Head of Bio AI - Radial

Leads technical direction for bio AI research programs, architects AI/computational infrastructure, prototypes modeling systems, and builds high-caliber engineering team. Requires deep ML expertise in generative models, large-scale training, and bio applications with hands-on leadership.

400k – 600k/yr
HybridML Engineering

About the role

Key Outcomes (12–24 Months)

Technical Architecture & Program Leadership

  • Establish AI and computational architecture across current and future programs, beginning with DiffUSE and its expansion across multiple structural biology data modalities.
  • Shape which foundational bottlenecks Radial addresses and how they become durable technical systems.
  • Help make build-vs-fund-vs-partner decisions across Radial’s program portfolio.

Hands-On Building

  • Conceive, architect, and directly prototype early modeling systems and core infrastructure.
  • Design scalable training workflows, data pipelines, validation frameworks, and evaluation benchmarks.
  • Evolve capabilities from early prototyping to production-grade, open platforms the scientific community can build on.

Team & Culture

  • Build a high-caliber AI and engineering team, starting small and scaling deliberately.
  • Set the technical bar through hands-on contribution and architectural authorship.
  • Establish a culture of technical rigor, intellectual honesty, and disciplined experimentation.

Ecosystem & Impact

  • Engage leading scientific collaborators and build technically rigorous partnerships.
  • Represent Radial’s technical vision within the AI and life sciences communities.
  • Ensure outputs are structured and shared as durable public goods.

Competencies

Functional Expertise

  • Deep expertise in modern ML: large-scale training, representation learning, generative modeling (diffusion, transformers, foundation models).
  • Track record of translating ideas into working, scalable systems.
  • Understanding of the interplay between machine learning and physics-based modeling.
  • Direct experience formulating and solving inverse problems, including familiarity with ill-posedness, regularization strategies, and the trade-offs between learned and model-based reconstruction approaches.
  • Experience building and iterating on ML pipelines for large-scale, data-intensive problems, including efficient data ingestion, preprocessing of high-dimensional inputs, and training workflows that scale across distributed compute resources.
  • Systems-level thinking across data generation, modeling, infrastructure, and experimentation.
  • Experience designing technical platforms intended to endure and compound over time.
  • Scientific range beyond a single modality can engage across problem domains.

Leadership Attributes

  • Has managed small technical teams; knows how to attract and retain exceptional talent.
  • Hands-on builder who sets the standard through their own work.
  • Deep familiarity with the frontier AI x Bio landscape.
  • Operates effectively in ambiguity; creates clarity through disciplined technical judgment.

Cultural Alignment

  • Motivated by the chance to build something that doesn’t exist yet.
  • Committed to open science and durable public infrastructure.
  • Thrives in early-stage, open-ended environments blending AI and biology.

Skills

Machine LearningDiffusion ModelsTransformersFoundation ModelsRepresentation LearningLarge-Scale TrainingData PipelinesDistributed ComputingGenerative ModelingInverse ProblemsPhysics-Based ModelingMl Pipelines

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