Skip to content
AsteraAstera

Principal Hardware Engineer, Precision Instrumentation

Design and build custom precision hardware systems (mechanical, electronic, optical) for large-scale neural experiments, owning instruments end-to-end from concept to reliable operation. Principal-level role also involves equipping the prototyping facility, mentoring engineers, and setting hardware engineering standards.

About the job

What You Will Build

  • Precision mechanical systems for experiments, such as titanium microfixtures, micrometer-precision electrode drives, and custom machined jigs.
  • Components for custom microscopes and optical systems, including alignment and mounting hardware.
  • Custom laboratory instrumentation and surgical or experimental robotics, designed and iterated alongside the scientists who depend on them.
  • Electronics and control hardware that interface mechanical systems with data acquisition and the rest of the research stack.
  • The design and prototyping facility itself: tooling, workflows, and fabrication capabilities that determine how fast the team can move.

What We Are Looking For

  • A world-class generalist and hands-on problem-solver who has built precision hardware in a high-precision industry, ideally medical devices, robotics, aerospace, semiconductor capital equipment, or commercial scientific instrumentation.
  • You have designed and built hardware that other people relied on for real work, and you kept it running.
  • Resourcefulness about getting things built quickly: you will machine one part, 3D-print the next, and send a job out for what is better outsourced.
  • Comfort working from a rough idea rather than a finished spec, figuring out the path to a working instrument together with the people who need it.
  • Deep fundamentals in mechanical design and fabrication, with real working ability in electronics or optics. You do not restrict yourself to what is familiar.
  • Intellectually curious, collaborative, and eager to learn the science around you.
  • A track record of owning complex instruments end-to-end, from concept through fabrication, integration, and reliable operation.
  • Experience making and defending design tradeoffs across performance, manufacturability, cost, and timeline.
  • Experience equipping and running a workshop, makerspace, or prototyping facility.
  • A history of mentoring engineers or setting engineering culture and standards.

Bonus

  • Experience with small precise parts, difficult materials, tight tolerances, precision motion, or optical alignment.
  • Hands-on electronics design (PCB layout, embedded systems, sensor/actuator integration).
  • Familiarity with electrophysiology or other low-volume, high-complexity hardware environments.
  • CAD/CAM proficiency with hands-on machining (CNC, lathe, mill) and 3D printing.
  • Experience integrating hardware with data acquisition systems (DAQ, TTL synchronization, serial/SPI protocols).

Education

Backgrounds in mechanical, electrical, or biomedical engineering, physics, or related fields are all welcome. Graduate work or research experience is a plus but not required.

Skills

Mechanical Design, Precision Machining, Electronics Design, Optics, Cad/Cam, Cnc Machining, 3D Printing, Pcb Layout, Embedded Systems, Data Acquisition Systems, Optical Alignment, Precision Motion

Shield AI

Shield AI

San Diego, CA

Principal Engineer, Electrical
$210k+/yrOn-site10+ YOEHardware Engineering

Leads flight-critical avionics and electrical subsystem design for autonomous aircraft, owning hardware development from concept through validation. Requires a bachelor’s degree or equivalent experience, 10+ years as an electrical engineer, and expertise in circuit design, testing, and debugging.

Dandy

Dandy

Indianapolis, IN

Staff Software Engineer, Manufacturing
$198k+/yrHybrid8+ YOEHardware Engineering

Senior Controls Engineer leading SCADA, PLC, and machine-software development for manufacturing equipment from proof of concept through high-volume production. The role requires 8+ years of software engineering experience, substantial manufacturing-software expertise, and frequent travel to Indianapolis and Provo.

Zoox

Zoox

Foster City, CA

Staff Electrical Architecture System Engineer
$204k+/yrOn-site15+ YOEHardware Engineering

Leads electrical architecture for autonomous vehicles, owning low-voltage power distribution, vehicle communications, ECU power states, and verification strategy. Requires extensive automotive electrical systems experience, model-based systems engineering expertise, and knowledge of ECU firmware and vehicle networks.

Skydio

Skydio

California

Staff Manufacturing Test Engineer
$196k+/yrOn-site10+ YOEHardware Engineering

Leads manufacturing test readiness for a product line, designing automated test hardware and software, analyzing factory data, and resolving production issues. Requires 10+ years of manufacturing engineering experience, 5+ years in NPI test development, and strong Python expertise.

Skydio

Skydio

California

Head of Manufacturing Engineering Automation & Controls
$196k+/yrOn-site12+ YOEHardware Engineering

Leads the manufacturing engineering organization responsible for scaling automated production systems for complex unmanned aircraft. The role requires deep factory automation and controls expertise, experience scaling electromechanical products, and a track record of leading multidisciplinary engineering teams.