Research Scientist / Engineer, Two-Photon Imaging & Holographic Optogenetics
Leads development of miniaturized two-photon microscopes for cellular-resolution imaging and holographic optogenetics in rodents. Requires PhD, hands-on surgery experience, two-photon systems expertise, and neural data analysis skills in Python/MATLAB.
Responsibilities
- Perform stereotaxic rodent surgeries: AAV viral vector delivery, chronic cranial window implantation, and GRIN lens or miniscope head-mount installation in mice and rats.
- Design, build, and iterate on a miniaturized two-photon microscope incorporating spatial light modulators for holographic photostimulation.
- Develop and optimize two-photon optogenetics protocols for single-cell and ensemble-level activation with minimal off-target excitation.
- Lead computational analysis of large-scale neural population data, including dimensionality reduction, population decoding, generalized linear models, and circuit-level inference.
- Collaborate with optical engineers, software developers, and neuroscientists to integrate hardware, software, and biology into a coherent experimental platform.
- Contribute to publications and internal technical documentation.
Requirements
- PhD in neuroscience, bioengineering, physics, or a related field, or equivalent demonstrated expertise.
- Hands-on rodent surgery experience: stereotaxic injection, cranial window preparation, and secure implant fixation in mice and/or rats.
- Practical experience with two-photon imaging systems, including optical alignment, system characterization, and in vivo use.
- Proficiency in scientific computing for neural data analysis: Python and/or MATLAB, with familiarity with Suite2p, CaImAn, or comparable pipelines.
- Strong foundational understanding of nonlinear optics, ultrafast laser physics, and fluorescence microscopy.
Nice-to-Haves
- Direct experience with two-photon optogenetics (SLM-based holography, temporal focusing, or spiral scanning photostimulation).
- Custom optical engineering with ultrafast pulsed lasers (Ti:Sapphire, fiber).
- Miniaturized imaging systems.
- Rat-scale stereotaxic surgery and freely moving behavioral paradigms.
- Machine learning applied to neural data.
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