Staff Scientist

Major Duties and Responsibilities

• Performs next-generation sequencing library preparation and sequencing using Illumina platforms, following established standard operating procedures (SOPs).
• Conducts RNA-seq and single-cell sequencing workflows, including sample preparation, library construction, sequencing setup, and post-run quality assessment.
• Performs nucleic acid extractions from diverse biological samples, including tissues, cells, and bacterial cultures.
• Supports project intake, sample tracking, and data documentation using laboratory information management systems (LIMS) and electronic lab notebooks.
• Assists with basic downstream data quality control and interpretation in collaboration with bioinformatics staff.
• Maintains accurate records of experiments, reagents, and sequencing runs to ensure reproducibility and regulatory compliance.
• Participates in laboratory maintenance, instrument performance monitoring, and routine troubleshooting under supervision.
• Follows all biosafety, chemical safety, and data security policies and completes required HHS/NIH training.
• Collaborates closely with investigators on consultations, experimental design, sample preparation, data analysis, and biological interpretation.
• Contributes to presentations, internal reports, and publications as appropriate.
• Researches, plans, and engages in technology development projects to further the capabilities of the genomics group.

Knowledge, Skills, and Abilities

• Working knowledge of Illumina sequencing platforms and NGS library preparation techniques.
• Familiarity with RNA-seq and single-cell sequencing technologies (e.g., 10x Genomics or equivalent platforms).
• Understanding of basic molecular biology techniques and experimental design.
• Ability to follow detailed protocols, maintain accurate documentation, and meet project deadlines.
• Strong organizational and communication skills to support a collaborative research environment.
• Willingness to learn new technologies and adapt to evolving research needs.

Qualifications

Education

• Ph.D. in Genomics, Molecular Biology, Genetics, or related biological science.

Experience

• Demonstrated hands-on experience with Illumina sequencing.
• Experience or formal training in RNA-seq and/or single-cell sequencing workflows.
• Experience working in a research laboratory or core facility environment.