# Principal Data Scientist

**Company:** [Formation Bio](https://hotfix.jobs/companies/formation-bio)
**Location:** New York, NY, Boston, MA
**Role:** Data Science
**Salary:** $205k – $267k/yr
**Experience:** 5+ years
**Skills:** Python, Machine Learning, Deep Learning, Bioinformatics, LLMs, Cloud Computing, Tabular Databases, Graph Databases, AI Agents, Biomarker Identification
**Posted:** 2026-04-28

> Lead AI and data science initiatives to advance drug development, focusing on patient stratification, biomarker identification, clinical trial optimization, and AI agent development for biomedical workflows. Requires PhD and 5+ years experience in life sciences with strong Python and bioinformatics skills.

## Job Description

## Responsibilities
- Lead and execute complex data science projects that directly advance our drug development portfolio
- Develop and implement sophisticated models for therapeutic hypothesis evaluation, including patient stratification and biomarker identification
- Design and create AI models for modernizing clinical trial evaluations, including surrogate endpoints
- Aid in the development and training of AI agents to automate and optimize biomedical workflows
- Collaborate cross-functionally with clinical, technical, and research teams
- Present complex analytical findings to senior stakeholders, including executive leadership

## Requirements
- PhD in computational sciences or life sciences
- 5+ years of post-academic experience in life sciences (biotech, pharma, consulting)
- Strong programming skills, particularly in Python
- Extensive experience in multi-modal bioinformatics analysis

## Preferred Qualifications
- Proven expertise in cloud computing environments, including proficiency with tabular and/or graph databases
- Strong background in machine learning and deep learning, particularly in biological applications
- Experience with large language models (LLM)
- Demonstrated ability to collaborate effectively with engineering teams on production systems
- Strong communication skills with proven ability to present complex technical findings to senior stakeholders

## Compensation and Benefits
- Total compensation range: $204,500 - $267,000
- Equity, comprehensive benefits, and generous perks

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