# Staff Scientist

**Company:** [Axle](https://hotfix.jobs/companies/axle)
**Location:** Hamilton, MT
**Role:** Other
**Salary:** $100k – $110k/yr
**Skills:** illumina sequencing, ngs library preparation, rna-seq, single-cell sequencing, 10x genomics, nucleic acid extraction, lims, molecular biology, experimental design, bioinformatics, genomics
**Posted:** 2026-07-30

> Staff Scientist providing scientific and technical support for next-generation sequencing projects, including Illumina sequencing, RNA-seq, and single-cell genomics workflows. Requires PhD in a relevant biological science and hands-on experience with these technologies in a research or core facility setting.

## Job Description

## Major Duties and Responsibilities

- Performs next-generation sequencing library preparation and sequencing using Illumina platforms, following established standard operating procedures (SOPs).
- Conducts RNA-seq and single-cell sequencing workflows, including sample preparation, library construction, sequencing setup, and post-run quality assessment.
- Performs nucleic acid extractions from diverse biological samples, including tissues, cells, and bacterial cultures.
- Supports project intake, sample tracking, and data documentation using laboratory information management systems (LIMS) and electronic lab notebooks.
- Assists with basic downstream data quality control and interpretation in collaboration with bioinformatics staff.
- Maintains accurate records of experiments, reagents, and sequencing runs to ensure reproducibility and regulatory compliance.
- Participates in laboratory maintenance, instrument performance monitoring, and routine troubleshooting under supervision.
- Follows all biosafety, chemical safety, and data security policies and completes required HHS/NIH training.
- Collaborates closely with investigators on consultations, experimental design, sample preparation, data analysis, and biological interpretation.
- Contributes to presentations, internal reports, and publications as appropriate.
- Researches, plans, and engages in technology development projects to further the capabilities of the genomics group.

## Knowledge, Skills, and Abilities

- Working knowledge of Illumina sequencing platforms and NGS library preparation techniques.
- Familiarity with RNA-seq and single-cell sequencing technologies (e.g., 10x Genomics or equivalent platforms).
- Understanding of basic molecular biology techniques and experimental design.
- Ability to follow detailed protocols, maintain accurate documentation, and meet project deadlines.
- Strong organizational and communication skills to support a collaborative research environment.
- Willingness to learn new technologies and adapt to evolving research needs.

## Qualifications

**Education**

- Ph.D. in Genomics, Molecular Biology, Genetics, or related biological science.

**Experience**

- Demonstrated hands-on experience with Illumina sequencing.
- Experience or formal training in RNA-seq and/or single-cell sequencing workflows.
- Experience working in a research laboratory or core facility environment.

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