# General DiffUSE Job Application

**Company:** [Astera](https://hotfix.jobs/companies/astera)
**Location:** Emeryville, CA
**Role:** ML Engineering
**Salary:** $100k – $300k/yr
**Skills:** Machine Learning, Structural Biology, Cryo-Em, Crystallography, Computational Biophysics, Data Pipelines, Open Source, Mmcif, Representation Learning, Geometric Deep Learning
**Posted:** 2026-05-21

> Open general application for computational biology, ML research, data science, software engineering, and program roles at DiffUSE, focused on protein dynamics, structural data infrastructure, and open science tooling.

## Job Description

## Role Categories We're Actively Building Around

### Computational and data science
- Diffraction data processing and structural data pipelines
- Multiconformer and heterogeneity analysis from large datasets
- Data standards work (mmCIF and related)
- Macromolecular ensemble metrics
- Machine learning research for macromolecules and biophysics
- Representation learning for protein dynamics
- ML on raw experimental data rather than processed structures
- 3D vision and geometric deep learning backgrounds especially welcome
- Dataset generation and open release
- Designing and running campaigns to generate large structural datasets
- Partnering with external collaborators to open and standardize existing datasets
- Bridging experimental facilities, data producers, and the open-science community

### Software and infrastructure engineering
- Scientific data infrastructure, pipelines, and tooling
- Open-source release engineering, reproducibility, and developer experience

### Program and operations
- Program management, scientific coordination, communications
- Open-science publishing and community building

## What We Look For Across All Roles
- Familiarity with protein biophysics and the experimental methods that generate structural data
- High agency: you identify what needs doing and move it forward without waiting for direction
- Ability to drive projects and people, including collaborators outside your reporting line
- Comfortable owning a problem end-to-end and unblocking collaborators
- Strong commitment to open science and public-good infrastructure
- Comfort working at the boundary between disciplines
- Bias toward shipping, iteration, and rapid feedback
- Clear written and verbal communication
- Track record of independent work inside collaborative teams

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**Apply:** https://hotfix.jobs/jobs/6676763d-f0db-437a-b47b-09135360f2b3
**Canonical:** https://hotfix.jobs/jobs/6676763d-f0db-437a-b47b-09135360f2b3