# Senior Backend Engineer

**Company:** [Orchestra Bio](https://hotfix.jobs/companies/orchestra-bio)
**Location:** San Francisco, CA
**Role:** Backend Engineering
**Experience:** 6+ years
**Skills:** TypeScript, Nestjs, Postgres, AWS, Azure, GCP, Containerization, Data Modeling, API Design, React, OpenAI, Anthropic, RAG
**Posted:** 2025-08-06

> Senior Backend Engineer builds scalable backend systems for R&D management platform in biotech, modeling complex decisions, aligning organizations, and integrating AI/LLMs for scenario analysis and insights. Requires 6+ years experience with TypeScript, NestJS, PostgreSQL, and cloud platforms.

## Job Description

## Responsibilities
- Build interactive tools for modeling paths to market, assessing trade-offs between time, money, and technical risk.
- Create intuitive interfaces for organizational alignment, visualizing complex dependencies and progress across teams (scientists, program managers, executives).
- Design interfaces for scientists to manage studies, track progress, and coordinate teams.
- Leverage LLMs to generate/evaluate scenarios, infer progress/risks from unstructured data, and surface insights from R&D portfolio.

## Requirements
**Required:**
- 6-8 years of backend development experience with production systems at scale.
- Deep expertise in **Typescript**, **NestJS**, **PostgreSQL**.
- Track record of building complex, scalable, reliable cloud-based software.
- Experience with cloud platforms (**AWS**/**Azure**/**GCP**) and containerization.
- Strong experience in data modeling and API design.
- Collaborative mindset with proven track record in small, fast-moving engineering teams.

**Preferred:**
- AI/ML integration with **OpenAI**, **Anthropic**, or similar LLM providers.
- Prompt engineering and RAG implementation experience.
- Full-stack capabilities (**React**/**TypeScript**).
- Track record of mentoring other engineers.

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**Apply:** https://hotfix.jobs/jobs/01257a63-343e-416b-b98d-7c2546e93811
**Canonical:** https://hotfix.jobs/jobs/01257a63-343e-416b-b98d-7c2546e93811